User blog comment:TheLovelyTerminator/Things in Supernatural could kill Meyerpires/@comment-7600752-20131210002536/@comment-24269116-20131210013932

Well, no, of course not, separate universe. But if they did share a universe, then all these things could kill Meyerpires. The Leviathans would do it purely out of spite, it'd be like stepping on bugs to them. Now here's the thing, Meyerpires are not as strong as they think they are, or even as strong as Meyer says they are. Aside from the fact that they are ridiculously flammable (like I said, these things would be way beneath demons and dragons) they can be killed by decapitation. Most of the things on this list can't even be killed by that. And then there's humans. We're already at a point where we could quite easily kill the Meyerpires. Wouldn't even have to send people in, just use drones and missiles. They can quite easily outpace a Meyerpire. I believe there's a list of weapons that could kill the Meyerpires on one of the pages on this wiki, I'll see if I can find it later.